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KMID : 0363220200580070453
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Korean Journal of Dermatology
2020 Volume.58 No. 7 p.453 ~ p.458
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Clinical Study of Specific Cutaneous Complications after BCG Vaccination
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Won Sang-Hyeon
Shin Ki-Hyuk
Kim Woo-Il
Yang Min-Young
Lee Won-Ku
Kim Hoon-Soo
Kim Byung-Soo
Kim Moon-Bum
Ko Hyun-Chang
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Abstract
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Background: Bacille Calmette-Guerin (BCG) vaccination has been widely used to prevent severe infections caused by Mycobacterium tuberculosis. Although BCG vaccination is generally safe, some cutaneous complications may occur. However, cutaneous complications related to BCG infection have been rarely investigated in Korea.
Objective: This study aimed to investigate the clinical characteristics of cutaneous complications following BCG vaccination in Korean patients.
Methods: We identified 18 patients with cutaneous complications following BCG vaccination in the Pusan National University Hospitals (Busan and Yangsan) from 2002 to 2019. Clinical manifestations and course were examined by the review of medical records and photographs.
Results: Among BCG-vaccinated persons, 18 patients manifested with BCG-specific cutaneous complications. The mean age of the patients was 10.6±10.1 months, and 10 (55.6%) were female. The specific cutaneous complications following BCG vaccination were local abscess (7, 38.9%), lymphadenitis (4, 22.2%), BCG reactivation in incomplete Kawasaki disease (4, 22.2%), tuberculid (3, 16.7%), and scrofuloderma (1, 5.6%). Disseminated BCG infection was detected in 2 brothers (11.1%) who had an immunocompromised state and a family history of BCG complication.
Conclusion: Specific cutaneous complications after BCG vaccination are rare, but may occur in various manifestations.
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KEYWORD
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Mycobacterium bovis, Kawasaki disease, Vaccination
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